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They found that sustained exposure to CC or ENDS caused a severe systemic inflammatory response, with increased activation of the NLRP3 inflammasome in neutrophils and macrophages, and enhanced dendritic cell-dependent activation of Th1 and Th17 cells in the lungs

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"Because of the associations between diacetyl and bronchiolitis obliterans urgent action is recommended to further evaluate the extent of this new exposure to diacetyl and related flavoring compounds in e-cigarettes," they wrote